About Haohong Pharmaceutical
Haohong has a high-level R&D team and a full range of analytical testing instruments and methods. At present, its production base in Liaocheng is equipped with 30 sets of 3,000–5,000L reactors, with an annual production capacity of 1,000 tons.
The company focuses on the development of active pharmaceutical ingredients and intermediates for anti-cancer, anti-hepatitis C and anti-diabetic therapies, with an emphasis on high-grade intermediates. Its main products include Bicalutamide, Enzalutamide, Apalutamide, Darolutamide, Abemaciclib, Venetoclax, Macitentan, Empagliflozin, Larotrectinib, Apixaban, Rivaroxaban, Ibrutinib, Ceritinib, Pomalidomide, Lenalidomide, Ivacaftor, Tofacitinib, Cabozantinib, Alectinib, etc.
Our products are exported to overseas markets including the United States, Europe, Japan, India, Bangladesh and other regions. The company currently has dozens of high-grade intermediates available for commercial production, and also provides customers with efficient custom synthesis services ranging from gram scale to hundreds of kilograms.
Adhering to the corporate philosophy of "Pragmatism, Innovation, Integrity", Haohong is committed to serving global customers with full dedication!
Our Products
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Abemaciclib Intermediate
Model: 4-Bromo-2,6-difluoroaniline
5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-amine
2-Bromo-5-formylpyridine
4-Fluoro-2-methyl-1-isopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Parameters: 4-Bromo-2,6-difluoroaniline
CAS: 1868-81-7
Molecular Formula: C₆H₄BrF₂N
Molecular Weight: 207.91
Appearance: White to off-white crystalline solid
Purity: ≥98.0% (HPLC/GC)
Density: 1.768±0.06 g/cm³
Boiling Point: 239.4±35.0 °C
Melting Point: 57–61 °C
Storage: Sealed, dry, keep away from light at 2–8 °C
Application: Abemaciclib pharmaceutical intermediate
5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-amine
CAS: 398565-53-2
Molecular Formula: C₁₂H₂₀N₄
Molecular Weight: 220.03
Appearance: Off-white to light yellow solid
Purity: ≥98.0% (HPLC)
Boiling Point: 368.5±42.0 °C
Density: 1.124±0.06 g/cm³
Storage: Sealed, low temperature and light protection
Application: Key intermediate for Abemaciclib
2-Bromo-5-formylpyridine
CAS: 100422-52-6
Molecular Formula: C₆H₄BrNO
Molecular Weight: 185.91
Appearance: White to light yellow solid
Purity: ≥98.0% (GC/HPLC)
Melting Point: 78–82 °C
Boiling Point: 286.3±30.0 °C
Storage: Sealed, dry, refrigerated preservation
Application: Heterocyclic intermediate for Abemaciclib synthesis
4-Fluoro-2-methyl-1-isopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole
CAS: 1356339-86-7
Appearance: White to off-white solid
Purity: ≥98.0% (HPLC)
Storage: Sealed, inert gas protection, 2–8 °C, avoid light
Application: Boronic acid ester intermediate for Abemaciclib
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CAS: 1356339-85-6
Appearance: White to light beige solid
Purity: ≥98.0% (HPLC)
Storage: Sealed, dry, low temperature and light-proof storage
Application: Core benzimidazole intermediate for Abemaciclib R&D and production
Alectinib Intermediate
Model: 2-(4-Ethylphenyl)-2-methylpropanoic acid
2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid
tert-Butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate
Parameters: 2-(4-Ethylphenyl)-2-methylpropanoic acid
CAS No.：1247119-83-0
Molecular Formula：C₁₂H₁₆O₂
Molecular Weight：192.26 g/mol
Appearance：White to off-white solid
Purity：≥98%
Density：1.047±0.06 g/cm³
Boiling Point：302.8±11.0 °C (760 mmHg)
Storage：2-8°C, sealed
Application：Alectinib intermediate
2-(4-Ethyl-3-iodophenyl)-2-methylpropanoic acid
CAS No.：1256584-73-2
Molecular Formula：C₁₂H₁₅IO₂
Molecular Weight：318.15 g/mol
Appearance：White to off-white solid
Purity：≥98%
Density：1.547±0.06 g/cm³
Boiling Point：369.6±27.0 °C (760 mmHg)
Storage：2-8°C, protect from light
Application：Alectinib intermediate
tert-Butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate
CAS No.：1256584-75-4
Molecular Formula：C₂₅H₂₇IN₂O₂
Molecular Weight：514.40 g/mol
Appearance：White to light yellow solid
Purity：≥98% (HPLC)
Storage：2-8°C, sealed, protect from light
Application：Alectinib key intermediate
Apalutamide Intermediate
Model: 2-Fluoro-4-nitrobenzoic acid
N-Methyl-2-fluoro-4-nitrobenzamide
N-Methyl-2-fluoro-4-aminobenzamide
N-Methyl-2-fluoro-4-bromobenzamide
Methyl 4-bromo-2-fluorobenzoate
2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine
5-Amino-3-(trifluoromethyl)pyridinecarbonitrile
Parameters: 2-Fluoro-4-nitrobenzoic acid
CAS: 403-24-7
Molecular Formula: C₇H₄FNO₄
Molecular Weight: 185.11
Appearance: White to light yellow solid
Melting Point: 170–176 °C
Boiling Point: 352.5±27 °C (predicted)
Density: 1.568±0.06 g/cm³ (predicted)
Purity: ≥98.0%
Storage: Sealed, dry, stored at room temperature
N-Methyl-2-fluoro-4-nitrobenzamide
CAS: 915087-24-0
Molecular Formula: C₈H₇FN₂O₃
Molecular Weight: 198.15
Appearance: Light yellow to yellow solid
Melting Point: Unavailable
Boiling Point: 337.1±32 °C (predicted)
Density: 1.358 g/cm³
Purity: ≥98.0% (HPLC)
Storage: Sealed, dry, stored at room temperature
N-Methyl-2-fluoro-4-aminobenzamide
CAS: 915087-25-1
Molecular Formula: C₈H₉FN₂O
Molecular Weight: 168.17
Appearance: Off-white solid
Melting Point: 160–163 °C
Boiling Point: Approx. 320 °C (estimated)
Density: Unavailable
Purity: ≥98.0% (HPLC)
Storage: Sealed, dry, stored at room temperature
N-Methyl-2-fluoro-4-bromobenzamide
CAS: 749927-69-3
Molecular Formula: C₈H₇BrFNO
Molecular Weight: 232.05
Appearance: White crystalline powder
Melting Point: Unavailable
Boiling Point: 284.8±30 °C
Density: 1.545±0.06 g/cm³
Purity: ≥98.0% (HPLC)
Storage: Sealed, dry, stored at room temperature
Methyl 4-bromo-2-fluorobenzoate
CAS: 179232-29-2
Molecular Formula: C₈H₆BrFO₂
Molecular Weight: 233.03
Appearance: White to off-white solid
Melting Point: 58–62 °C
Boiling Point: 272.7±25 °C
Density: 1.577±0.06 g/cm³
Purity: ≥98.0% (GC)
Storage: Sealed, dry, stored at room temperature
2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine
CAS: 99368-66-8
Molecular Formula: C₆H₃F₃N₂O₃
Molecular Weight: 208.09
Appearance: Light yellow solid
Melting Point: 158 °C
Boiling Point: 276.2±40 °C (predicted)
Density: 1.61±0.1 g/cm³ (predicted)
Purity: ≥97%~≥98%
Storage: Sealed, dry, stored at room temperature
5-Amino-3-(trifluoromethyl)pyridinecarbonitrile
CAS: 573762-62-6
CAS: 573762-62-6
Molecular Formula: C₇H₄F₃N₃
Molecular Weight: 187.12
Appearance: Off-white to yellow solid
Melting Point: Unavailable
Boiling Point: 362.2±42 °C (predicted)
Density: 1.45±0.1 g/cm³ (predicted)
Purity: ≥97%~≥99.0%
Storage: Keep away from light, stored at room temperature under inert atmosphere
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Top-tier Pharmaceutical Group
1High reaction yield reduces the production cost of finished pharmaceuticals.
2Low levels of impurities, heavy metals and residual solvents minimize drug safety risks.
3Stable quality across batches improves the consistency of customers’ pharmaceutical production.
4Simplified downstream synthesis processes shorten drug development cycles.
5Accelerates the drug registration process.
Ultra‑high purity with strictly controlled impurities, heavy metals and residual solvents.
Consistent quality batch‑to‑batch, stable crystal form and particle size.
Strict compliance with ICH, GMP and international pharmaceutical standards.
Stable large‑scale production capacity and reliable supply chain.
Customizable R&D support for API synthesis and drug registration.
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