4-Bromo-2,6-Difluoroaniline CAS 1868-81-7 for Abemaciclib Intermediate

Name: "4-Bromo-2,6-Difluoroaniline CAS 1868-81-7 for Abemaciclib Intermediate"
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SKU: 4431737227

Model: 4-Bromo-2,6-difluoroaniline 5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-amine 2-Bromo-5-formylpyridine 4-Fluoro-2-methyl-1-isopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

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Product Details

Product Summary

4-Bromo-2,6-difluoroaniline (CAS 1868-81-7) is a specialized halogenated aniline derivative used as a key pharmaceutical intermediate in the synthesis of Abemaciclib, an anticancer drug for targeted therapy. With a purity of ≥98.0% (HPLC/GC) and a well-defined crystalline form, this intermediate ensures reliable performance in downstream coupling and amination reactions.

Key Selling Points

High Purity ≥98.0% (HPLC/GC): Minimizes impurities to reduce downstream purification complexity and improve API yield.
Stable Crystalline Form: Consistent physical properties (melting point 57–61°C) ensure predictable handling and storage in production environments.
Specific CAS 1868-81-7: Verified identity for reproducible synthesis and regulatory documentation.
Low-Moisture Storage Requirements: Sealed, dry storage at 2–8°C ensures long-term stability and batch integrity.
Core Intermediate for Abemaciclib: Directly supports the synthesis of the active pharmaceutical ingredient, enabling efficient drug production.

Technical Specifications

Parameter	Value
CAS Number	1868-81-7
Molecular Formula	C₆H₄BrF₂N
Molecular Weight	207.91
Appearance	White to off-white crystalline solid
Purity	≥98.0% (HPLC/GC)
Density	1.768±0.06 g/cm³
Boiling Point	239.4±35.0 °C
Melting Point	57–61 °C
Storage Conditions	Sealed, dry, keep away from light at 2–8 °C

Models and Options

Available in research quantities (grams) and commercial batches (up to hundreds of kilograms) per customer requirements. Custom packaging and COA documentation provided.

Materials and Structure

Halogenated aniline aromatic compound with fluorine and bromine substitutions on the benzene ring. This structural motif is essential for the C–N and C–C bond formations in Abemaciclib synthesis.

Applications

Pharmaceutical manufacturing industry, particularly in anti-cancer drug synthesis and targeted therapy development. Used in the production of Abemaciclib API and related innovative drug R&D.

FAQ

What is the purity grade available?

We supply ≥98.0% purity (HPLC/GC) as standard.

How is this intermediate stored?

Sealed, dry, away from light at 2–8°C to maintain stability.

Can you provide custom packaging?

Yes, packaging can be customized based on order quantity.

Is this product suitable for large-scale API production?

Yes, it is used in commercial production of Abemaciclib intermediates.

Do you offer quality documentation?

Yes, each batch is supplied with a COA.

Inquiry Information

For inquiries, contact: Xu Tianxia, Email: Xutx@haohong-pharma.com, Tel: +86 180-6854-1569.

4-Bromo-2,6-difluoroaniline crystalline solid for Abemaciclib intermediate